| Gene Information | |
|---|---|
| Gene Name | CD74 |
| Organism | Homo sapiens (Human) |
| Gene Length | 296 |
| Protein Names | HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)] |
| Target Name | hla-dr antigens-associated invariant |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000019582 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P04233 |
| Gene Card | CD74 |
| Uniprot ID | P04233 |
| Pfam | PF09307; PF08831; PF00086 |
| In ASD | no |
| Allosteric Prediction | yes (0.404518794) |
| Ortholog in Animals | Alpaca_ CD74 ( ortholog_one2one ) Dog_ CD74 ( ortholog_one2one ) GuineaPig_ CD74 ( ortholog_one2one ) Macaque_ CD74 ( ortholog_one2one ) Mouse_ Cd74 ( ortholog_one2one ) Pig_ CD74 ( ortholog_one2one ) Rat_ Cd74 ( ortholog_one2one ) Rabbit_ CD74 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [Isoform p41]: In B cells, represents 10% of total CD74 expression. {ECO:0000269|PubMed:3104027}.; [Isoform p33]: In B cells, represents 70% of total CD74 expression. {ECO:0000269|PubMed:3104027}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A6A (X-ray 2.75A ) 1ICF (X-ray 2.00A ) 1IIE (NMR - ) 1L3H (NMR - ) 1MUJ (X-ray 2.15A ) 3PDO (X-ray 1.95A ) 3PGC (X-ray 2.66A ) 3PGD (X-ray 2.72A ) 3QXA (X-ray 2.71A ) 3QXD (X-ray 2.30A ) 4AEN (X-ray 2.20A ) 4AH2 (X-ray 2.36A ) 4X5W (X-ray 1.34A ) 5KSU (X-ray 2.73A ) 5KSV (X-ray 2.19A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; [Isoform p41]: Late endosome {ECO:0000250|UniProtKB:P04441}. Lysosome {ECO:0000250|UniProtKB:P04441}. |
| Mouse PG classification | NA |
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