| Gene Information | |
|---|---|
| Gene Name | CD46 |
| Organism | Homo sapiens (Human) |
| Gene Length | 392 |
| Protein Names | Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000117335 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P15529 |
| Gene Card | CD46 |
| Uniprot ID | P15529 |
| Pfam | PF00084 |
| In ASD | no |
| Allosteric Prediction | yes (0.383990465) |
| Ortholog in Animals | Alpaca_ CD46 ( ortholog_one2one ) Macaque_ CD46 ( ortholog_one2one ) Mouse_ Cd46 ( ortholog_one2one ) Rat_ RGD1559810 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | NA |
| Tissue Specificity | Expressed by all cells except erythrocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CKL (X-ray 3.10A ) 2O39 (X-ray 2.85A ) 3INB (X-ray 3.10A ) 3L89 (X-ray 3.50A ) 3O8E (X-ray 2.84A ) 5FO8 (X-ray 2.40A ) |
| DBSNP | rs138843816 rs121909591 rs780693519 rs759136081 rs1271761432 rs121909589 rs17006830 rs41317833 rs35366573 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane {ECO:0000269|PubMed:12112588, ECO:0000269|PubMed:14597734, ECO:0000269|PubMed:15307194}; Single-pass type I membrane protein {ECO:0000269|PubMed:12112588, ECO:0000269|PubMed:14597734, ECO:0000269|PubMed:15307194}. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide. |
| Mouse PG classification | NA |
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