| Gene Information | |
|---|---|
| Gene Name | CD44 |
| Organism | Homo sapiens (Human) |
| Gene Length | 742 |
| Protein Names | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) |
| Target Name | cd44 antigen |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000026508 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P16070 |
| Gene Card | CD44 |
| Uniprot ID | P16070 |
| Pfam | PF00193 |
| In ASD | no |
| Allosteric Prediction | yes (1.040188465) |
| Ortholog in Animals | Alpaca_ CD44 ( ortholog_one2one ) Dog_ CD44 ( ortholog_one2one ) GuineaPig_ CD44 ( ortholog_one2one ) Macaque_ CD44 ( ortholog_one2one ) Mouse_ Cd44 ( ortholog_one2one ) Pig_ CD44 ( ortholog_one2one ) Rat_ Cd44 ( ortholog_one2one ) Rabbit_ CD44 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LYVE1 |
| Tissue | NA |
| Tissue Specificity | Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1POZ (NMR - ) 1UUH (X-ray 2.20A ) 2I83 (NMR - ) 4PZ3 (X-ray 1.08A ) 4PZ4 (X-ray 1.60A ) 6TXS (X-ray 2.20A ) |
| DBSNP | rs369473842 rs11607491 rs9666607 rs1467558 rs12273397 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P15379}. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. Localizes to cholesterol-rich membrane-bound lipid raft domains. {ECO:0000250|UniProtKB:P15379, ECO:0000269|PubMed:23589287}. |
| Mouse PG classification | NA |
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