| Gene Information | |
|---|---|
| Gene Name | CRLF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 371 |
| Protein Names | Cytokine receptor-like factor 2 (Cytokine receptor-like 2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 36 ( ENSG00000205755 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9HC73 |
| Gene Card | CRLF2 |
| Uniprot ID | Q9HC73 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.383647431) |
| Ortholog in Animals | Alpaca_ CRLF2 ( ortholog_one2one ) Dog_ CRLF2 ( ortholog_one2one ) Mouse_ Crlf2 ( ortholog_one2one ) Rat_ Crlf2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5J11 (X-ray 2.56A ) 5J12 (X-ray 3.55A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 2]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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