| Gene Information | |
|---|---|
| Gene Name | CD4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 458 |
| Protein Names | T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4) |
| Target Name | t-cell surface glycoprotein cd4 |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000010610 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01730 |
| Gene Card | CD4 |
| Uniprot ID | P01730 |
| Pfam | PF05790; PF09191; PF00047; PF12104 |
| In ASD | no |
| Allosteric Prediction | yes (1.613478593) |
| Ortholog in Animals | Alpaca_ CD4 ( ortholog_one2one ) Dog_ CD4 ( ortholog_one2one ) Macaque_ CD4 ( ortholog_one2one ) Mouse_ Cd4 ( ortholog_one2one ) Pig_ CD4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. {ECO:0000269|PubMed:16951326, ECO:0000269|PubMed:24942581, ECO:0000269|PubMed:8088877}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1CDH (X-ray 2.30A ) 1CDI (X-ray 2.90A ) 1CDJ (X-ray 2.50A ) 1CDU (X-ray 2.70A ) 1CDY (X-ray 2.00A ) 1G9M (X-ray 2.20A ) 1G9N (X-ray 2.90A ) 1GC1 (X-ray 2.50A ) 1JL4 (X-ray 4.30A ) 1Q68 (NMR - ) 1RZJ (X-ray 2.20A ) 1RZK (X-ray 2.90A ) 1WBR (NMR - ) 1WIO (X-ray 3.90A ) 1WIP (X-ray 4.00A ) 1WIQ (X-ray 5.00A ) 2B4C (X-ray 3.30A ) 2JKR (X-ray 2.98A ) 2JKT (X-ray 3.40A ) 2KLU (NMR - ) 2NXY (X-ray 2.00A ) 2NXZ (X-ray 2.04A ) 2NY0 (X-ray 2.20A ) 2NY1 (X-ray 1.99A ) 2NY2 (X-ray 2.00A ) 2NY3 (X-ray 2.00A ) 2NY4 (X-ray 2.00A ) 2NY5 (X-ray 2.50A ) 2NY6 (X-ray 2.80A ) 2QAD (X-ray 3.30A ) 3B71 (X-ray 2.82A ) 3CD4 (X-ray 2.20A ) 3J70 (EM - ) 3JCB (EM - ) 3JCC (EM - ) 3JWD (X-ray 2.61A ) 3JWO (X-ray 3.51A ) 3LQA (X-ray 3.40A ) 3O2D (X-ray 2.19A ) 3S4S (X-ray 2.40A ) 3S5L (X-ray 2.10A ) 3T0E (X-ray 4.00A ) 4H8W (X-ray 1.85A ) 4JM2 (X-ray 3.10A ) 4P9H (X-ray 3.00A ) 4Q6I (X-ray 3.65A ) 4R2G (X-ray 3.28A ) 4R4H (X-ray 4.28A ) 4RQS (X-ray 4.49A ) 5A7X (EM 17.00A ) 5A8H (EM 23.00A ) 5CAY (X-ray 3.00A ) 5THR (EM 8.90A ) 5U1F (EM 6.80A ) 5VN3 (EM 3.70A ) 6CM3 (EM 3.54A ) 6EDU (EM 4.06A ) 6L1Y (X-ray 2.47A ) 6MEO (EM 3.90A ) 6MET (EM 4.50A ) 6OPN (EM 3.50A ) 6OPO (EM 3.50A ) 6OPP (EM 3.70A ) 6OPQ (EM 3.80A ) 6QH6 (X-ray 5.00A ) 6QH7 (X-ray 3.40A ) 6U0L (EM 3.30A ) 6U0N (EM 3.50A ) 6URI (X-ray 3.00A ) 6X5B (EM 3.60A ) 6X5C (EM 4.04A ) 7T0O (EM 8.70A ) 7T0R (X-ray 3.65A ) |
| DBSNP | rs28917504 rs11064419 rs28919570 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12089508, ECO:0000269|PubMed:12517957, ECO:0000269|PubMed:2823150, ECO:0000269|PubMed:2990730}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957, ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:1708753}. Note=Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
| Mouse PG classification | NA |
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