| Gene Information | |
|---|---|
| Gene Name | GIMAP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 307 |
| Protein Names | GTPase IMAP family member 5 (Immune-associated nucleotide-binding protein 5) (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated nucleotide 5 protein) (IAN-5) (hIAN5) (Immunity-associated protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000196329 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96F15 |
| Gene Card | GIMAP5 |
| Uniprot ID | Q96F15 |
| Pfam | PF04548 |
| In ASD | no |
| Allosteric Prediction | no (-1.056648656) |
| Ortholog in Animals | Alpaca_ GIMAP5 ( ortholog_one2one ) Alpaca_ GIMAP1 ( ortholog_one2many ) Dog_ GIMAP5 ( ortholog_one2one ) GuineaPig_ GIMAP5 ( ortholog_one2one ) Macaque_ GIMAP5 ( ortholog_one2one ) Mouse_ Gimap3 ( ortholog_one2many ) Mouse_ Gimap5 ( ortholog_one2many ) Rat_ Gimap5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GIMAP6, GIMAP4, GIMD1, GIMAP1, GIMAP2, GIMAP7, GIMAP8 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with high levels in lymph node and spleen (PubMed:14724691). High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes (PubMed:14724691, PubMed:29382851). Very low expression levels in B-lymphocytes (PubMed:14724691). {ECO:0000269|PubMed:14724691, ECO:0000269|PubMed:29382851}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6Z3E (X-ray 2.80A ) |
| DBSNP | rs72650695 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:21487483, ECO:0000269|PubMed:29382851}; Single-pass type IV membrane protein {ECO:0000305}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:21487483}; Single-pass type IV membrane protein {ECO:0000305}. Endosome membrane {ECO:0000250|UniProtKB:Q8K3L6}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8K3L6}. Note=The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. {ECO:0000305|PubMed:14724691, ECO:0000305|PubMed:21487483}. |
| Mouse PG classification | NA |
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