| Gene Information | |
|---|---|
| Gene Name | CD38 |
| Organism | Homo sapiens (Human) |
| Gene Length | 300 |
| Protein Names | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38) |
| Target Name | cyclic adp-ribose hydrolase 1 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000004468 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P28907 |
| Gene Card | CD38 |
| Uniprot ID | P28907 |
| Pfam | PF02267 |
| In ASD | no |
| Allosteric Prediction | yes (1.119871666) |
| Ortholog in Animals | Alpaca_ CD38 ( ortholog_one2one ) Dog_ CD38 ( ortholog_one2one ) Macaque_ CD38 ( ortholog_one2one ) Mouse_ Cd38 ( ortholog_one2one ) Pig_ CD38 ( ortholog_one2one ) Rat_ Cd38 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BST1 |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. {ECO:0000269|PubMed:9074508}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YH3 (X-ray 1.91A ) 1ZVM (X-ray 2.20A ) 2EF1 (X-ray 2.40A ) 2HCT (X-ray 1.95A ) 2I65 (X-ray 1.90A ) 2I66 (X-ray 1.70A ) 2I67 (X-ray 1.71A ) 2O3Q (X-ray 1.98A ) 2O3R (X-ray 1.75A ) 2O3S (X-ray 1.50A ) 2O3T (X-ray 1.68A ) 2O3U (X-ray 2.11A ) 2PGJ (X-ray 1.71A ) 2PGL (X-ray 1.76A ) 3DZF (X-ray 2.01A ) 3DZG (X-ray 1.65A ) 3DZH (X-ray 1.60A ) 3DZI (X-ray 1.73A ) 3DZJ (X-ray 1.90A ) 3DZK (X-ray 1.81A ) 3F6Y (X-ray 1.45A ) 3I9M (X-ray 1.75A ) 3I9N (X-ray 2.01A ) 3OFS (X-ray 2.20A ) 3RAJ (X-ray 3.04A ) 3ROK (X-ray 1.65A ) 3ROM (X-ray 2.04A ) 3ROP (X-ray 1.94A ) 3ROQ (X-ray 2.10A ) 3U4H (X-ray 1.88A ) 3U4I (X-ray 2.12A ) 4CMH (X-ray 1.53A ) 4F45 (X-ray 2.10A ) 4F46 (X-ray 1.69A ) 4OGW (X-ray 2.05A ) 4TMF (X-ray 2.05A ) 4XJS (X-ray 2.80A ) 4XJT (X-ray 2.60A ) 5F1K (X-ray 2.30A ) 5F1O (X-ray 2.20A ) 5F21 (X-ray 1.90A ) 6EDR (X-ray 2.40A ) 6VUA (X-ray 1.50A ) 7DHA (X-ray 2.55A ) 7DUO (X-ray 2.81A ) 7VKE (X-ray 1.90A ) |
| DBSNP | rs1800561 |
| Subcellular location [CC] | Membrane; Single-pass type II membrane protein. |
| Mouse PG classification | NA |
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