| Gene Information | |
|---|---|
| Gene Name | RPS6KA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 735 |
| Protein Names | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) |
| Target Name | ribosomal protein s6 kinase alpha-1 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000117676 ) 3 ( ENSG00000281877 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q15418 |
| Gene Card | RPS6KA1 |
| Uniprot ID | Q15418 |
| Pfam | PF00069; PF00433 |
| In ASD | yes |
| Allosteric Prediction | yes (0.913828327) |
| Ortholog in Animals | Alpaca_ RPS6KA1 ( ortholog_one2one ) Dog_ RPS6KA1 ( ortholog_one2one ) GuineaPig_ RPS6KA1 ( ortholog_one2one ) Macaque_ RPS6KA1 ( ortholog_one2one ) Mouse_ Rps6ka1 ( ortholog_one2one ) Pig_ RPS6KA1 ( ortholog_one2one ) Rat_ Rps6ka1 ( ortholog_one2one ) Rabbit_ RPS6KA1 ( ortholog_one2one ) |
| Ohnologs | RPS6KA2, RPS6KA6, RPS6KA3 |
| Paralogs | RPS6KA5, RPS6KB1, RPS6KA3, RPS6KA2, RPS6KB2, RPS6KA4, RPS6KA6 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2WNT (X-ray 2.40A ) 2Z7Q (X-ray 2.00A ) 2Z7R (X-ray 2.00A ) 2Z7S (X-ray 2.10A ) 3RNY (X-ray 2.70A ) 3TEI (X-ray 2.40A ) 4H3P (X-ray 2.30A ) 4NIF (X-ray 2.15A ) 5CSF (X-ray 2.40A ) 5CSI (X-ray 2.13A ) 5CSJ (X-ray 2.70A ) 5CSN (X-ray 2.95A ) 5N7D (X-ray 2.30A ) 5N7F (X-ray 2.30A ) 5N7G (X-ray 2.95A ) 5V61 (X-ray 2.20A ) 5V62 (X-ray 1.90A ) 6TWY (X-ray 2.30A ) 7P74 (X-ray 1.90A ) 7PC8 (X-ray 2.50A ) 7QQL (X-ray 2.44A ) |
| DBSNP | rs2229712 |
| Subcellular location [CC] | Nucleus. Cytoplasm. |
| Mouse PG classification | NA |
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