| Gene Information | |
|---|---|
| Gene Name | SIGLEC8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 499 |
| Protein Names | Sialic acid-binding Ig-like lectin 8 (Siglec-8) (Sialoadhesin family member 2) (SAF-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000105366 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NYZ4 |
| Gene Card | SIGLEC8 |
| Uniprot ID | Q9NYZ4 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-1.214526617) |
| Ortholog in Animals | Alpaca_ SIGLEC8 ( ortholog_one2one ) Mouse_ Siglece ( ortholog_one2many ) Rat_ Siglec8 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | MAG, SIGLECL1, CD22, SIGLEC7, SIGLEC9, SIGLEC12, CD33, SIGLEC6, SIGLEC5, SIGLEC14, SIGLEC11, SIGLEC16, SIGLEC10, SIGLEC1, SIGLEC15, TMEM25 |
| Tissue | NA |
| Tissue Specificity | Expressed specifically on red blood cells namely basophil, mast cells and eosinophils. {ECO:0000269|PubMed:10625619, ECO:0000269|PubMed:10856141}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2N7A (NMR - ) 2N7B (NMR - ) |
| DBSNP | rs10409962 rs3829659 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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