| Gene Information | |
|---|---|
| Gene Name | CD2AP |
| Organism | Homo sapiens (Human) |
| Gene Length | 639 |
| Protein Names | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000198087 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y5K6 |
| Gene Card | CD2AP |
| Uniprot ID | Q9Y5K6 |
| Pfam | PF00018; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.294626739) |
| Ortholog in Animals | Alpaca_ CD2AP ( ortholog_one2one ) Dog_ CD2AP ( ortholog_one2one ) GuineaPig_ CD2AP ( ortholog_one2one ) Macaque_ CD2AP ( ortholog_one2one ) Mouse_ Cd2ap ( ortholog_one2one ) Pig_ CD2AP ( ortholog_one2one ) Rat_ Cd2ap ( ortholog_one2one ) |
| Ohnologs | SH3KBP1 |
| Paralogs | NOSTRIN, SH3D21, SH3KBP1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in fetal and adult tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001928(Rat);0.030303(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2FEI (NMR - ) 2J6F (X-ray 1.70A ) 2J6K (X-ray 2.78A ) 2J6O (X-ray 2.22A ) 2J7I (X-ray 2.90A ) 3AA6 (X-ray 1.90A ) 3LK4 (X-ray 1.99A ) 3U23 (X-ray 1.11A ) 4WCI (X-ray 1.65A ) 4X1V (X-ray 1.58A ) 7DS6 (X-ray 1.69A ) 7DS8 (X-ray 1.95A ) |
| DBSNP | rs34069459 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15800069}. Cell projection, ruffle {ECO:0000269|PubMed:10339567}. Cell junction {ECO:0000269|PubMed:22891260}. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles (PubMed:10339567). Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (PubMed:15800069). {ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069}. |
| Mouse PG classification | HPG |
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