| Gene Information | |
|---|---|
| Gene Name | CD28 |
| Organism | Homo sapiens (Human) |
| Gene Length | 220 |
| Protein Names | T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28) |
| Target Name | t-cell-specific surface glycoprotein cd28 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000178562 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10747 |
| Gene Card | CD28 |
| Uniprot ID | P10747 |
| Pfam | PF15910 |
| In ASD | no |
| Allosteric Prediction | yes (0.372052723) |
| Ortholog in Animals | Alpaca_ CD28 ( ortholog_one2one ) Dog_ CD28 ( ortholog_one2one ) GuineaPig_ CD28 ( ortholog_one2one ) Macaque_ CD28 ( ortholog_one2one ) Mouse_ Cd28 ( ortholog_one2one ) Pig_ CD28 ( ortholog_one2one ) Rat_ Cd28 ( ortholog_one2one ) Rabbit_ CD28 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CTLA4 |
| Tissue | appendix, lymph.node, placenta, tonsil |
| Tissue Specificity | Expressed in T-cells and plasma cells, but not in less mature B-cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YJD (X-ray 2.70A ) 3WA4 (X-ray 1.35A ) 5AUL (X-ray 1.10A ) 5GJH (X-ray 1.20A ) 5GJI (X-ray 0.90A ) 6O8D (X-ray 3.55A ) 7PPN (X-ray 1.90A ) 7VU5 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface {ECO:0000269|PubMed:15067037}. |
| Mouse PG classification | NA |
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