| Gene Information | |
|---|---|
| Gene Name | CD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 351 |
| Protein Names | T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2) |
| Target Name | t-cell surface antigen cd2 |
| Target Type | Clinical trial target |
| Gene Age | 132 ( ENSG00000116824 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P06729 |
| Gene Card | CD2 |
| Uniprot ID | P06729 |
| Pfam | PF05790; PF07686 |
| In ASD | no |
| Allosteric Prediction | yes (0.296985552) |
| Ortholog in Animals | Alpaca_ CD2 ( ortholog_one2one ) Dog_ CD2 ( ortholog_one2one ) GuineaPig_ CD2 ( ortholog_one2one ) Macaque_ CD2 ( ortholog_one2one ) Mouse_ Cd2 ( ortholog_one2one ) Pig_ CD2 ( ortholog_one2one ) Rat_ Cd2 ( ortholog_one2one ) Rabbit_ CD2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLAMF1, CD244, SLAMF8, LY9, SLAMF7, SLAMF9, SLAMF6, CD84, CD48 |
| Tissue | small.intestine.Peyers.patch, spleen, whole.blood |
| Tissue Specificity | Expressed in natural killer cells (at protein level). {ECO:0000269|PubMed:23006327}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005276(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CDB (NMR - ) 1GYA (NMR - ) 1HNF (X-ray 2.50A ) 1L2Z (NMR - ) 1QA9 (X-ray 3.20A ) 2J6O (X-ray 2.22A ) 2J7I (X-ray 2.90A ) |
| DBSNP | rs699738 rs35880225 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23006327, ECO:0000269|PubMed:2437578}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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