| Gene Information | |
|---|---|
| Gene Name | CD1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 327 |
| Protein Names | T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a) |
| Target Name | t-cell surface glycoprotein cd1a |
| Target Type | NA |
| Gene Age | 70 ( ENSG00000158477 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P06126 |
| Gene Card | CD1A |
| Uniprot ID | P06126 |
| Pfam | PF07654; PF16497 |
| In ASD | no |
| Allosteric Prediction | yes (0.029965284) |
| Ortholog in Animals | Alpaca_ CD1A ( ortholog_one2one ) Dog_ CD1A8 ( ortholog_one2one ) Macaque_ CD1A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HLA-B, HLA-E, HLA-A, HLA-F, HLA-G, HLA-C, MR1, AZGP1, MICA, HFE, MICB, CD1C, CD1D, CD1E, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, RAET1E, ULBP3, ULBP1 |
| Tissue | skin |
| Tissue Specificity | Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:18178838}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ONQ (X-ray 2.15A ) 1XZ0 (X-ray 2.80A ) 4X6C (X-ray 2.80A ) 4X6D (X-ray 2.98A ) 4X6E (X-ray 2.10A ) 4X6F (X-ray 1.91A ) 5J1A (X-ray 1.86A ) 6NUX (X-ray 2.20A ) 7KOZ (X-ray 2.25A ) 7KP0 (X-ray 2.40A ) 7KP1 (X-ray 2.02A ) 7RYM (X-ray 3.20A ) 7RYN (X-ray 2.70A ) 7RYO (X-ray 3.00A ) |
| DBSNP | rs3087217 rs2269714 rs2269715 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:11600221, ECO:0000269|PubMed:18178838}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:18178838}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:11231314}; Single-pass type I membrane protein {ECO:0000255}. Note=Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838). {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:18178838}. |
| Mouse PG classification | NA |
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