Gene Information
Gene NameCD163
OrganismHomo sapiens (Human)
Gene Length1156
Protein NamesScavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)]
Target Namescavenger receptor cysteine-rich type 1 protein m130
Target TypeNA
Gene Age987 ( ENSG00000177575 )
Evolutionary StageEumetazoa
AlphaFoldDBQ86VB7
Gene CardCD163
Uniprot IDQ86VB7
PfamPF00530
In ASDno
Allosteric Predictionyes (0.395256801)
Ortholog in AnimalsAlpaca_ CD163 ( ortholog_one2one )
Dog_ CD163 ( ortholog_one2one )
GuineaPig_ CD163 ( ortholog_one2one )
Macaque_ CD163 ( ortholog_one2one )
Mouse_ Cd163 ( ortholog_one2one )
Pig_ CD163 ( ortholog_one2one )
Rat_ Cd163 ( ortholog_one2one )
Rabbit_ CD163 ( ortholog_one2one )
OhnologsNA
ParalogsCD6, LOX, SSC4D, SSC5D, LGALS3BP, LOXL4, SCART1, PRSS12, DMBT1, LOXL3, CD5, LOXL1, CD5L, LOXL2, CD163L1
TissueNA
Tissue SpecificityExpressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood. {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:11196644, ECO:0000269|PubMed:16434690}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs4883263 
Subcellular location [CC][Soluble CD163]: Secreted {ECO:0000269|PubMed:12296867}.;
Cell membrane {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:10648003};
Single-pass type I membrane protein {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:10648003}. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.
Mouse PG classificationNA
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