| Gene Information | |
|---|---|
| Gene Name | CLPP |
| Organism | Homo sapiens (Human) |
| Gene Length | 277 |
| Protein Names | ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp) |
| Target Name | putative atp-dependent clp protease proteolytic subunit, mitochondrial |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000125656 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q16740 |
| Gene Card | CLPP |
| Uniprot ID | Q16740 |
| Pfam | PF00574 |
| In ASD | yes |
| Allosteric Prediction | yes (0.78720997) |
| Ortholog in Animals | Alpaca_ CLPP ( ortholog_one2one ) Dog_ CLPP ( ortholog_one2one ) GuineaPig_ CLPP ( ortholog_one2one ) Macaque_ CLPP ( ortholog_one2one ) Mouse_ Clpp ( ortholog_one2one ) Pig_ CLPP ( ortholog_one2one ) Rat_ Clpp ( ortholog_one2one ) Rabbit_ CLPP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney. {ECO:0000269|PubMed:10525407, ECO:0000269|PubMed:8543061}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1TG6 (X-ray 2.10A ) 6BBA (X-ray 2.80A ) 6DL7 (X-ray 2.00A ) 6H23 (X-ray 3.09A ) 7VP9 (X-ray 2.55A ) |
| DBSNP | rs398123033 rs398123034 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000269|PubMed:10525407, ECO:0000269|PubMed:22354088}. |
| Mouse PG classification | NA |
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