| Gene Information | |
|---|---|
| Gene Name | CD152 |
| Organism | Homo sapiens (Human) |
| Gene Length | 223 |
| Protein Names | Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P16410 |
| Gene Card | CTLA4 |
| Uniprot ID | P16410 |
| Pfam | PF07686 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. {ECO:0000269|PubMed:10493833, ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1713603}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AH1 (NMR - ) 1H6E (X-ray 3.60A ) 1I85 (X-ray 3.20A ) 1I8L (X-ray 3.00A ) 2X44 (X-ray 2.60A ) 3BX7 (X-ray 2.10A ) 3OSK (X-ray 1.80A ) 5GGV (X-ray 2.00A ) 5TRU (X-ray 3.00A ) 5XJ3 (X-ray 3.20A ) 6RP8 (X-ray 2.60A ) 6RPJ (X-ray 3.25A ) 6RQM (X-ray 3.00A ) 6XY2 (X-ray 3.05A ) 7CIO (X-ray 1.10A ) 7DV4 (X-ray 2.38A ) 7ELX (X-ray 2.14A ) 7SU0 (X-ray 2.41A ) 7SU1 (X-ray 2.53A ) |
| DBSNP | rs231775 rs606231422 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18468488, ECO:0000269|PubMed:28484017}; Single-pass type I membrane protein {ECO:0000269|PubMed:18468488, ECO:0000269|PubMed:28484017}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization. |
| Mouse PG classification | NA |
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