| Gene Information | |
|---|---|
| Gene Name | CD13 |
| Organism | Homo sapiens (Human) |
| Gene Length | 967 |
| Protein Names | Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P15144 |
| Gene Card | ANPEP |
| Uniprot ID | P15144 |
| Pfam | PF11838; PF01433; PF17900 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients. {ECO:0000269|PubMed:7902291}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4FYQ (X-ray 1.90A ) 4FYR (X-ray 1.91A ) 4FYS (X-ray 2.01A ) 4FYT (X-ray 1.85A ) 5LHD (X-ray 2.60A ) 6ATK (X-ray 3.50A ) 6U7E (X-ray 3.00A ) 6U7F (X-ray 2.75A ) 6U7G (X-ray 2.35A ) 6XWD (X-ray 1.60A ) 7AEW (X-ray 1.20A ) 7VPQ (X-ray 3.10A ) |
| DBSNP | rs10152474 rs25653 rs17240268 rs8179199 rs17240212 rs8192297 rs25651 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:2564851, ECO:0000269|PubMed:9056417}; Single-pass type II membrane protein {ECO:0000305|PubMed:1350662}. Note=Also found as a soluble form. {ECO:0000269|PubMed:7902291}. |
| Mouse PG classification | NA |
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