| Gene Information | |
|---|---|
| Gene Name | CCT4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 539 |
| Protein Names | T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000115484 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P50991 |
| Gene Card | CCT4 |
| Uniprot ID | P50991 |
| Pfam | PF00118 |
| In ASD | no |
| Allosteric Prediction | yes (0.110726319) |
| Ortholog in Animals | Alpaca_ CCT4 ( ortholog_one2one ) Alpaca_ CCT4 ( ortholog_one2many ) Dog_ CCT4 ( ortholog_one2one ) GuineaPig_ CCT4 ( ortholog_one2one ) Macaque_ CCT4 ( ortholog_one2one ) Mouse_ Cct4 ( ortholog_one2one ) Pig_ CCT4 ( ortholog_one2one ) Rat_ Cct4 ( ortholog_one2one ) Rabbit_ CCT4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TCP1, BBS12, CCT2, CCT6A, CCT6B, CCT7, CCT5, HSPD1, CCT8L2, CCT8, CCT3, PIKFYVE, MKKS |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.023505(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6NR8 (EM 7.80A ) 6NR9 (EM 8.50A ) 6NRA (EM 7.70A ) 6NRB (EM 8.70A ) 6NRC (EM 8.30A ) 6NRD (EM 8.20A ) 6QB8 (EM 3.97A ) 7LUM (EM 4.50A ) 7LUP (EM 6.20A ) 7NVL (EM 2.50A ) 7NVM (EM 3.10A ) 7NVN (EM 3.00A ) 7NVO (EM 3.50A ) |
| DBSNP | rs2272428 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:20080638}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P80315}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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