Gene Information
Gene NameCCR6
OrganismHomo sapiens (Human)
Gene Length344
Protein NamesC-C chemokine receptor-like 2 (Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000112486 )
Evolutionary StageEumetazoa
AlphaFoldDBO00421
Gene CardCCRL2
Uniprot IDO00421
PfamPF00001
In ASDno
Allosteric Predictionyes (0.283569022)
Ortholog in AnimalsDog_ CCR6 ( ortholog_one2one )
GuineaPig_ CCR6 ( ortholog_one2one )
Macaque_ CCR6 ( ortholog_one2one )
Mouse_ Ccr6 ( ortholog_one2one )
Pig_ CCR6 ( ortholog_one2one )
Rat_ Ccr6 ( ortholog_one2one )
Rabbit_ CCR6 ( ortholog_one2one )
OhnologsAGTR2, CX3CR1, CCR9, CCR8, CCR3, CCR4
ParalogsCCR9, CXCR6, CCR7, ACKR4, CCR10, GALR2, XCR1, RGR, ACKR3, CCRL2, CCR8, CCR1, ACKR2, CCR4, CX3CR1, CCR2, CCR5, CCR3, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3
TissueNA
Tissue SpecificityExpressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients. {ECO:0000269|PubMed:11828366, ECO:0000269|PubMed:15188357, ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:9473515}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs11574443  rs3204849  rs6441977  rs3204850 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784};
Multi-pass membrane protein {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784}.
Mouse PG classificationNA
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