Gene Information
Gene NameCCR6
OrganismHomo sapiens (Human)
Gene Length374
Protein NamesC-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000112486 )
Evolutionary StageEumetazoa
AlphaFoldDBP51684
Gene CardCCR6
Uniprot IDP51684
PfamPF00001
In ASDyes
Allosteric Predictionyes (0.283569022)
Ortholog in AnimalsDog_ CCR6 ( ortholog_one2one )
GuineaPig_ CCR6 ( ortholog_one2one )
Macaque_ CCR6 ( ortholog_one2one )
Mouse_ Ccr6 ( ortholog_one2one )
Pig_ CCR6 ( ortholog_one2one )
Rat_ Ccr6 ( ortholog_one2one )
Rabbit_ CCR6 ( ortholog_one2one )
OhnologsAGTR2, CX3CR1, CCR9, CCR8, CCR3, CCR4
ParalogsCCR9, CXCR6, CCR7, ACKR4, CCR10, GALR2, XCR1, RGR, ACKR3, CCRL2, CCR8, CCR1, ACKR2, CCR4, CX3CR1, CCR2, CCR5, CCR3, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3
TissueNA
Tissue SpecificitySperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes. {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:8886020}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6WWZ  (EM  3.34A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:23765988};
Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:12081481}.
Mouse PG classificationNA
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