| Gene Information | |
|---|---|
| Gene Name | CCR5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 352 |
| Protein Names | C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195) |
| Target Name | c-c chemokine receptor type 5 |
| Target Type | Successful target |
| Gene Age | 382 ( ENSG00000160791 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P51681 |
| Gene Card | CCR5 |
| Uniprot ID | P51681 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.683696556) |
| Ortholog in Animals | Alpaca_ CCR5 ( ortholog_one2one ) Dog_ CCR5 ( ortholog_one2one ) Macaque_ CCR5 ( ortholog_one2one ) Mouse_ Ccr5 ( ortholog_one2one ) Pig_ CCR5 ( ortholog_one2one ) Rat_ Ccr5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3, GALR2, XCR1, RGR, ACKR3, CCR2, CCRL2, CCR1, CCR3, CCR4, CCR8, CX3CR1, ACKR2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. {ECO:0000269|PubMed:8639485, ECO:0000269|PubMed:8663314}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L87 (NMR - ) 2MZX (NMR - ) 2RLL (NMR - ) 2RRS (NMR - ) 4MBS (X-ray 2.71A ) 5UIW (X-ray 2.20A ) 5YD3 (X-ray 1.35A ) 5YD4 (X-ray 1.35A ) 5YD5 (X-ray 1.96A ) 5YY4 (X-ray 1.59A ) 6FGP (NMR - ) 6MEO (EM 3.90A ) 6MET (EM 4.50A ) 7F1Q (EM 2.90A ) 7F1R (EM 3.00A ) 7F1S (EM 2.80A ) 7NJZ (X-ray 3.20A ) 7NW3 (X-ray 3.20A ) 7O7F (EM 3.15A ) |
| DBSNP | rs145061115 rs1800939 rs56340326 rs1475319259 rs1799863 rs1800940 rs758090461 rs56198941 rs149975182 rs183662584 rs199824195 rs1017863136 rs1800452 rs143181119 rs534088482 rs1800943 rs1800944 rs1800945 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10383387, ECO:0000269|PubMed:11323418}; Multi-pass membrane protein {ECO:0000269|PubMed:11323418}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |