| Gene Information | |
|---|---|
| Gene Name | CCR4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 557 |
| Protein Names | CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase) |
| Target Name | c-c chemokine receptor type 4 |
| Target Type | Successful target |
| Gene Age | 382 ( ENSG00000183813 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9ULM6 |
| Gene Card | CNOT6 |
| Uniprot ID | Q9ULM6 |
| Pfam | PF03372; PF13855 |
| In ASD | no |
| Allosteric Prediction | yes (1.000245097) |
| Ortholog in Animals | Alpaca_ CCR4 ( ortholog_one2one ) Dog_ CCR4 ( ortholog_one2one ) GuineaPig_ Ccr4 ( ortholog_one2one ) Macaque_ CCR4 ( ortholog_one2one ) Mouse_ Ccr4 ( ortholog_one2one ) Pig_ CCR4 ( ortholog_one2one ) Rat_ Ccr4 ( ortholog_one2one ) |
| Ohnologs | CCR6, LPAR4, CMKLR1, CCR10, CXCR3, CXCR4, ACKR3, AGTR1, CXCR1, CXCR2 |
| Paralogs | CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3, GALR2, XCR1, RGR, ACKR3, CCRL2, CCR1, CCR2, CCR5, CCR3, CCR8, CX3CR1, ACKR2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.064(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7AX1 (X-ray 3.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q96LI5}. Nucleus {ECO:0000250|UniProtKB:Q96LI5}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q96LI5}. |
| Mouse PG classification | NA |
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