| Gene Information | |
|---|---|
| Gene Name | CCR4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 431 |
| Protein Names | Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein) |
| Target Name | c-c chemokine receptor type 4 |
| Target Type | Successful target |
| Gene Age | 382 ( ENSG00000183813 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UK39 |
| Gene Card | NOCT |
| Uniprot ID | Q9UK39 |
| Pfam | PF03372 |
| In ASD | no |
| Allosteric Prediction | yes (1.000245097) |
| Ortholog in Animals | Alpaca_ CCR4 ( ortholog_one2one ) Dog_ CCR4 ( ortholog_one2one ) GuineaPig_ Ccr4 ( ortholog_one2one ) Macaque_ CCR4 ( ortholog_one2one ) Mouse_ Ccr4 ( ortholog_one2one ) Pig_ CCR4 ( ortholog_one2one ) Rat_ Ccr4 ( ortholog_one2one ) |
| Ohnologs | CCR6, LPAR4, CMKLR1, CCR10, CXCR3, CXCR4, ACKR3, AGTR1, CXCR1, CXCR2 |
| Paralogs | CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3, GALR2, XCR1, RGR, ACKR3, CCRL2, CCR1, CCR2, CCR5, CCR3, CCR8, CX3CR1, ACKR2 |
| Tissue | NA |
| Tissue Specificity | Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue. {ECO:0000269|PubMed:22331129}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.075(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6BT1 (X-ray 1.48A ) 6BT2 (X-ray 2.41A ) 6MAL (X-ray 2.60A ) 6NF0 (X-ray 2.70A ) |
| DBSNP | rs2271777 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:O35710}. Nucleus {ECO:0000250|UniProtKB:O35710}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O35710}. Mitochondrion {ECO:0000269|PubMed:31147539}. |
| Mouse PG classification | NA |
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