| Gene Information | |
|---|---|
| Gene Name | CCR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 355 |
| Protein Names | C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193) |
| Target Name | c-c chemokine receptor type 3 |
| Target Type | Discontinued target |
| Gene Age | 382 ( ENSG00000183625 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P51677 |
| Gene Card | CCR3 |
| Uniprot ID | P51677 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.023386692) |
| Ortholog in Animals | Alpaca_ CCR3 ( ortholog_one2one ) Dog_ CCR3 ( ortholog_one2one ) GuineaPig_ CCR3 ( ortholog_one2one ) Macaque_ CCR3 ( ortholog_one2one ) Mouse_ Ccr3 ( ortholog_one2one ) Rat_ Ccr3 ( ortholog_one2one ) |
| Ohnologs | CCR6, CCR7, CXCR4 |
| Paralogs | CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3, GALR2, XCR1, RGR, ACKR3, CCR1, CCRL2, CCR2, CCR5, CCR4, CCR8, CX3CR1, ACKR2 |
| Tissue | NA |
| Tissue Specificity | In eosinophils as well as trace amounts in neutrophils and monocytes. {ECO:0000269|PubMed:8676064}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7X9Y (EM 3.10A ) |
| DBSNP | rs4987125 rs5742906 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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