| Gene Information | |
|---|---|
| Gene Name | PKCE |
| Organism | Homo sapiens (Human) |
| Gene Length | 737 |
| Protein Names | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q02156 |
| Gene Card | PRKCE |
| Uniprot ID | Q02156 |
| Pfam | PF00130; PF00168; PF00069; PF00433 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in cumulus cells (at protein level). {ECO:0000269|PubMed:19542546}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.008(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WH0 (X-ray 2.25A ) 5LIH (X-ray 3.25A ) |
| DBSNP | rs772834505 rs55989965 rs55767130 rs34077350 rs35777875 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:19542546}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17603037}. Cell membrane {ECO:0000269|PubMed:17603037}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P16054}. Nucleus {ECO:0000250|UniProtKB:P16054}. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF (PubMed:17603037). Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). {ECO:0000250|UniProtKB:P16054, ECO:0000269|PubMed:17603037}. |
| Mouse PG classification | NA |
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