| Gene Information | |
|---|---|
| Gene Name | CCNF |
| Organism | Homo sapiens (Human) |
| Gene Length | 786 |
| Protein Names | Cyclin-F (F-box only protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000162063 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P41002 |
| Gene Card | CCNF |
| Uniprot ID | P41002 |
| Pfam | PF02984; PF00134; PF00646 |
| In ASD | no |
| Allosteric Prediction | no (-0.514873815) |
| Ortholog in Animals | Alpaca_ CCNF ( ortholog_one2one ) Dog_ CCNF ( ortholog_one2one ) GuineaPig_ CCNF ( ortholog_one2one ) Macaque_ CCNF ( ortholog_one2one ) Mouse_ Ccnf ( ortholog_one2one ) Pig_ CCNF ( ortholog_one2one ) Rat_ Ccnf ( ortholog_one2one ) Rabbit_ CCNF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCND1, CCNB1, CCNE2, CCNG1, CCNB3, CCNB2, CCNA1, CCNI, CCNP, CCNA2, CCNE1, CCNI2, CCNG2, CCNJL, CCND2, CCNJ, CCNO, CCND3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with expression detected in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:7813445}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs944306963 rs1465313712 rs745821656 rs1371569927 rs954539468 rs760953006 rs756914411 rs778264897 rs771621178 rs762663630 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10716937, ECO:0000269|PubMed:22632967, ECO:0000269|PubMed:26818844, ECO:0000269|PubMed:7813445}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:7813445}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:20596027}. Note=Localization to the centrosome is rare in S phase cells and increases in G2 cells. Localizes to both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Localizes to the nucleus in G2 phase. {ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:26818844}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |