| Gene Information | |
|---|---|
| Gene Name | KCNJ16 |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Inward rectifier potassium channel 16 (Inward rectifier K(+) channel Kir5.1) (Potassium channel, inwardly rectifying subfamily J member 16) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000153822 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9NPI9 |
| Gene Card | KCNJ16 |
| Uniprot ID | Q9NPI9 |
| Pfam | PF01007; PF17655 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000300373) |
| Ortholog in Animals | Alpaca_ KCNJ16 ( ortholog_one2one ) Dog_ KCNJ16 ( ortholog_one2one ) GuineaPig_ KCNJ16 ( ortholog_one2one ) Macaque_ KCNJ16 ( ortholog_one2one ) Mouse_ Kcnj16 ( ortholog_one2one ) Pig_ KCNJ16 ( ortholog_one2one ) Rat_ Kcnj16 ( ortholog_one2one ) Rabbit_ KCNJ16 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KCNJ9, KCNJ3, KCNJ5, KCNJ6, KCNJ11, KCNJ15, KCNJ10, KCNJ13, KCNJ8, KCNJ1, KCNJ14, KCNJ18, KCNJ4, KCNJ12, KCNJ2 |
| Tissue | kidney, thyroid, cortex.of.kidney |
| Tissue Specificity | Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts. {ECO:0000269|PubMed:11060447, ECO:0000269|PubMed:11240146, ECO:0000269|PubMed:24561201}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs9302912 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:24561201}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:24561201}. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. {ECO:0000269|PubMed:24561201}. |
| Mouse PG classification | NA |
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