| Gene Information | |
|---|---|
| Gene Name | CCN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 357 |
| Protein Names | CCN family member 3 (Cellular communication network factor 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephro blastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000136999 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P48745 |
| Gene Card | CCN3 |
| Uniprot ID | P48745 |
| Pfam | PF00007; PF00219; PF19035; PF00093 |
| In ASD | no |
| Allosteric Prediction | no (-0.432798289) |
| Ortholog in Animals | Alpaca_ CCN3 ( ortholog_one2one ) Dog_ CCN3 ( ortholog_one2one ) GuineaPig_ CCN3 ( ortholog_one2one ) Macaque_ CCN3 ( ortholog_one2one ) Mouse_ Ccn3 ( ortholog_one2one ) Pig_ CCN3 ( ortholog_one2one ) Rat_ Ccn3 ( ortholog_one2one ) Rabbit_ CCN3 ( ortholog_one2one ) |
| Ohnologs | CCN5, CCN2, CCN1 |
| Paralogs | CCN6, CCN1, CCN2, CCN5, CCN4 |
| Tissue | NA |
| Tissue Specificity | Expressed in endiothelial cells (at protein level) (PubMed:21063504). Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type. {ECO:0000269|PubMed:1756408, ECO:0000269|PubMed:21063504}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2279112 rs11538929 |
| Subcellular location [CC] | Secreted. Cytoplasm {ECO:0000269|PubMed:15181016}. Cell junction, gap junction {ECO:0000269|PubMed:15181016}. Note=Localizes at the gap junction in presence of GJA1. {ECO:0000250|UniProtKB:Q9QZQ5}. |
| Mouse PG classification | NA |
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