| Gene Information | |
|---|---|
| Gene Name | CCN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 349 |
| Protein Names | CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8) |
| Target Name | ccn2 messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000118523 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P29279 |
| Gene Card | CCN2 |
| Uniprot ID | P29279 |
| Pfam | PF00007; PF00219; PF19035; PF00093 |
| In ASD | no |
| Allosteric Prediction | yes (0.505800194) |
| Ortholog in Animals | Alpaca_ CCN2 ( ortholog_one2one ) Dog_ CCN2 ( ortholog_one2one ) GuineaPig_ CCN2 ( ortholog_one2one ) Macaque_ CCN2 ( ortholog_one2one ) Mouse_ Ccn2 ( ortholog_one2one ) Pig_ CCN2 ( ortholog_one2one ) Rat_ Ccn2 ( ortholog_one2one ) Rabbit_ CCN2 ( ortholog_one2one ) |
| Ohnologs | CCN5, CCN4, CCN3 |
| Paralogs | CCN6, CCN3, CCN1, CCN5, CCN4 |
| Tissue | NA |
| Tissue Specificity | Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. {ECO:0000269|PubMed:1756408}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7451102 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P29268}. Secreted {ECO:0000250|UniProtKB:P29268}. |
| Mouse PG classification | NA |
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