| Gene Information | |
|---|---|
| Gene Name | PRPF40A |
| Organism | Homo sapiens (Human) |
| Gene Length | 957 |
| Protein Names | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000196504 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75400 |
| Gene Card | PRPF40A |
| Uniprot ID | O75400 |
| Pfam | PF01846; PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.631803584) |
| Ortholog in Animals | Alpaca_ PRPF40A ( ortholog_one2one ) Dog_ PRPF40A ( ortholog_one2one ) GuineaPig_ PRPF40A ( ortholog_one2one ) Macaque_ PRPF40A ( ortholog_one2one ) Mouse_ Prpf40a ( ortholog_one2one ) Pig_ PRPF40A ( ortholog_one2one ) Rat_ Prpf40a ( ortholog_one2one ) |
| Ohnologs | PRPF40B |
| Paralogs | PRPF40B |
| Tissue | NA |
| Tissue Specificity | Expressed in the brain cortex (at protein level). Widely expressed. {ECO:0000269|PubMed:16391387, ECO:0000269|PubMed:9700202}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1UZC (NMR - ) 1YWI (NMR - ) 1YWJ (NMR - ) 1ZR7 (NMR - ) 2CQN (NMR - ) 2DYF (NMR - ) 2KZG (NMR - ) 2L5F (NMR - ) 2L9V (NMR - ) 2LKS (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000269|PubMed:16391387}. Note=Colocalizes with AKAP8L in the nuclear matrix. {ECO:0000250}. |
| Mouse PG classification | NA |
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