| Gene Information | |
|---|---|
| Gene Name | CCL8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 99 |
| Protein Names | C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)] |
| Target Name | c-c motif chemokine 8 |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000108700 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P80075 |
| Gene Card | CCL8 |
| Uniprot ID | P80075 |
| Pfam | PF00048 |
| In ASD | no |
| Allosteric Prediction | no (-0.689841352) |
| Ortholog in Animals | Alpaca_ CCL8 ( ortholog_one2one ) Dog_ CCL8 ( ortholog_one2one ) Macaque_ CCL8 ( ortholog_one2one ) Pig_ CCL8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCL25, CCL21, XCL1, CCL20, CCL19, XCL2, CCL22, CCL17, CCL11, CCL7, CCL13, CCL2, CCL15, CCL18, CCL24, CCL3L3, CCL4, CCL16, CCL26, CCL4L2, CCL3, CCL23, CCL14, CCL1, CX3CL1 |
| Tissue | NA |
| Tissue Specificity | Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ESR (X-ray 2.00A ) 7S59 (X-ray 2.39A ) 7S5A (X-ray 1.37A ) |
| DBSNP | rs35401229 rs1133763 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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