| Gene Information | |
|---|---|
| Gene Name | PIM3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 326 |
| Protein Names | Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) |
| Target Name | serine/threonine-protein kinase pim-3 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000198355 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86V86 |
| Gene Card | PIM3 |
| Uniprot ID | Q86V86 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.307961456) |
| Ortholog in Animals | Alpaca_ PIM3 ( ortholog_one2one ) Dog_ PIM3 ( ortholog_one2one ) GuineaPig_ PIM3 ( ortholog_one2one ) Macaque_ PIM3 ( ortholog_one2one ) Mouse_ Pim3 ( ortholog_one2one ) Pig_ PIM3 ( ortholog_one2one ) Rat_ Pim3 ( ortholog_one2one ) |
| Ohnologs | PIM2, PIM1 |
| Paralogs | PIM2, PIM1 |
| Tissue | NA |
| Tissue Specificity | Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17876606}. |
| Mouse PG classification | NA |
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