| Gene Information | |
|---|---|
| Gene Name | MAT2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 395 |
| Protein Names | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) |
| Target Name | s-adenosylmethionine synthase isoform type-2 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000168906 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P31153 |
| Gene Card | MAT2A |
| Uniprot ID | P31153 |
| Pfam | PF02773; PF02772; PF00438 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999565028) |
| Ortholog in Animals | Alpaca_ MAT2A ( ortholog_one2one ) Dog_ MAT2A ( ortholog_one2one ) GuineaPig_ MAT2A ( ortholog_one2one ) Macaque_ MAT2A ( ortholog_one2one ) Mouse_ Mat2a ( ortholog_one2one ) Pig_ MAT2A ( ortholog_one2one ) Rat_ Mat2a ( ortholog_one2many ) Rat_ RGD1560523 ( ortholog_one2many ) Rabbit_ MAT2A ( ortholog_one2one ) |
| Ohnologs | MAT1A |
| Paralogs | MAT1A |
| Tissue | NA |
| Tissue Specificity | Detected in kidney. {ECO:0000269|PubMed:1426236}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2P02 (X-ray 1.21A ) 4KTT (X-ray 2.59A ) 4KTV (X-ray 3.30A ) 4NDN (X-ray 2.34A ) 5A19 (X-ray 2.34A ) 5A1G (X-ray 1.83A ) 5A1I (X-ray 1.09A ) 5UGH (X-ray 2.06A ) 6FAJ (X-ray 1.95A ) 6FBN (X-ray 2.70A ) 6FBO (X-ray 1.80A ) 6FBP (X-ray 1.65A ) 6FCB (X-ray 2.70A ) 6FCD (X-ray 1.70A ) 6FWB (X-ray 1.79A ) 6G6R (X-ray 1.35A ) 6P9V (X-ray 2.05A ) 6WKB (X-ray 2.55A ) 7BHR (X-ray 1.08A ) 7BHS (X-ray 1.05A ) 7BHT (X-ray 1.05A ) 7BHU (X-ray 1.15A ) 7BHV (X-ray 1.16A ) 7BHW (X-ray 1.15A ) 7BHX (X-ray 1.08A ) 7KCC (X-ray 1.32A ) 7KCE (X-ray 1.14A ) 7KCF (X-ray 1.10A ) 7KDA (X-ray 1.24A ) 7KDB (X-ray 1.24A ) 7L1A (X-ray 1.25A ) 7LNH (X-ray 2.50A ) 7RW5 (X-ray 2.48A ) 7RW7 (X-ray 1.19A ) 7RWG (X-ray 0.97A ) 7RWH (X-ray 1.17A ) 7RXV (X-ray 1.07A ) 7RXW (X-ray 1.07A ) 7RXX (X-ray 1.25A ) |
| DBSNP | NA |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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