| Gene Information | |
|---|---|
| Gene Name | DIAPH3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1193 |
| Protein Names | Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000139734 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NSV4 |
| Gene Card | DIAPH3 |
| Uniprot ID | Q9NSV4 |
| Pfam | PF06367; PF06371; PF02181 |
| In ASD | no |
| Allosteric Prediction | no (-0.263905625) |
| Ortholog in Animals | Alpaca_ DIAPH3 ( ortholog_one2one ) GuineaPig_ DIAPH3 ( ortholog_one2one ) Macaque_ DIAPH3 ( ortholog_one2one ) Mouse_ Diaph3 ( ortholog_one2one ) Pig_ DIAPH3 ( ortholog_one2one ) Rat_ Diaph3 ( ortholog_one2one ) Rabbit_ DIAPH3 ( ortholog_one2one ) |
| Ohnologs | DIAPH2, DIAPH1 |
| Paralogs | FHOD3, FHOD1, FHDC1, GRID2IP, FAM47B, DAAM2, FNBP4, SHTN1, FAM47C, FAM47A, FMNL1, DAAM1, DIAPH2, FMN2, FMNL3, FMNL2, INF2, DIAPH1 |
| Tissue | testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5UWP (X-ray 2.05A ) 6X2Y (X-ray 2.30A ) |
| DBSNP | rs36084898 rs35579086 rs7491389 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18755006, ECO:0000269|PubMed:19457867}. Nucleus {ECO:0000250|UniProtKB:Q9Z207}. Note=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis (PubMed:18755006, PubMed:19457867). Shuttles between the cytoplasm and the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9Z207, ECO:0000269|PubMed:18755006, ECO:0000269|PubMed:19457867}. |
| Mouse PG classification | LPG |
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