| Gene Information | |
|---|---|
| Gene Name | CCL21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 134 |
| Protein Names | C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000137077 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O00585 |
| Gene Card | CCL21 |
| Uniprot ID | O00585 |
| Pfam | PF00048 |
| In ASD | no |
| Allosteric Prediction | no (-0.122447394) |
| Ortholog in Animals | Alpaca_ CCL21 ( ortholog_one2one ) Dog_ CCL21 ( ortholog_one2one ) GuineaPig_ CCL21 ( ortholog_one2one ) Macaque_ CCL21 ( ortholog_one2one ) Mouse_ Ccl21a ( ortholog_one2many ) Mouse_ Ccl21b ( ortholog_one2many ) Mouse_ Gm10591 ( ortholog_one2many ) Mouse_ Gm13304 ( ortholog_one2many ) Mouse_ Ccl21d ( ortholog_one2many ) Pig_ CCL21 ( ortholog_one2one ) Rat_ Ccl21 ( ortholog_one2one ) Rabbit_ CCL21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCL25, XCL1, CCL19, XCL2, CCL22, CCL17, CCL20, CCL15, CCL18, CX3CL1, CCL24, CCL3L3, CCL2, CCL4, CCL1, CCL16, CCL13, CCL8, CCL7, CCL11, CCL26, CCL4L2, CCL3, CCL23, CCL14 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L4N (NMR - ) 5EKI (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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