| Gene Information | |
|---|---|
| Gene Name | CCL20 |
| Organism | Homo sapiens (Human) |
| Gene Length | 96 |
| Protein Names | C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)] |
| Target Name | liver and activation-regulated chemokine |
| Target Type | Clinical trial target |
| Gene Age | 332 ( ENSG00000115009 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P78556 |
| Gene Card | CCL20 |
| Uniprot ID | P78556 |
| Pfam | PF00048 |
| In ASD | no |
| Allosteric Prediction | yes (0.147725871) |
| Ortholog in Animals | Alpaca_ CCL20 ( ortholog_one2one ) GuineaPig_ CCL20 ( ortholog_one2one ) Macaque_ CCL20 ( ortholog_one2one ) Mouse_ Ccl20 ( ortholog_one2one ) Rabbit_ CCL20 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCL25, CCL21, XCL1, CCL19, XCL2, CCL22, CCL17, CCL15, CCL18, CX3CL1, CCL24, CCL3L3, CCL2, CCL4, CCL1, CCL16, CCL13, CCL8, CCL7, CCL11, CCL26, CCL4L2, CCL3, CCL23, CCL14 |
| Tissue | appendix, lymph.node, tongue, tricuspid.valve, lung |
| Tissue Specificity | Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon. {ECO:0000269|PubMed:11352563, ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:9013939, ECO:0000269|PubMed:9038201, ECO:0000269|PubMed:9129037}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1M8A (X-ray 1.70A ) 2HCI (X-ray 1.81A ) 2JYO (NMR - ) 5UR7 (X-ray 2.00A ) 6WWZ (EM 3.34A ) |
| DBSNP | rs1049617 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11035086}. |
| Mouse PG classification | NA |
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