| Gene Information | |
|---|---|
| Gene Name | CCL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 99 |
| Protein Names | C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2) |
| Target Name | monocyte chemotactic and activating factor |
| Target Type | Clinical trial target |
| Gene Age | 244 ( ENSG00000108691 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P13500 |
| Gene Card | CCL2 |
| Uniprot ID | P13500 |
| Pfam | PF00048 |
| In ASD | no |
| Allosteric Prediction | yes (0.071151312) |
| Ortholog in Animals | Alpaca_ CCL2 ( ortholog_one2one ) Dog_ CCL2 ( ortholog_one2one ) Macaque_ CCL2 ( ortholog_one2one ) Mouse_ Ccl2 ( ortholog_one2one ) Pig_ CCL2 ( ortholog_one2one ) Rat_ Ccl2 ( ortholog_one2one ) Rabbit_ CCL2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCL25, CCL21, XCL1, CCL20, CCL19, XCL2, CCL22, CCL17, CCL13, CCL8, CCL7, CCL11, CCL15, CCL18, CCL24, CCL3L3, CCL4, CCL16, CCL26, CCL4L2, CCL3, CCL23, CCL14, CCL1, CX3CL1 |
| Tissue | NA |
| Tissue Specificity | Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477). {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:2513477}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DOK (X-ray 1.85A ) 1DOL (X-ray 2.40A ) 1DOM (NMR - ) 1DON (NMR - ) 1ML0 (X-ray 2.80A ) 2BDN (X-ray 2.53A ) 2NZ1 (X-ray 2.50A ) 3IFD (X-ray 1.90A ) 4DN4 (X-ray 2.80A ) 4R8I (X-ray 2.05A ) 4ZK9 (X-ray 2.60A ) 7SO0 (X-ray 1.74A ) 7XA3 (EM 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:2513477}. |
| Mouse PG classification | LPG |
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