| Gene Information | |
|---|---|
| Gene Name | SCIMP |
| Organism | Homo sapiens (Human) |
| Gene Length | 145 |
| Protein Names | SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000161929 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q6UWF3 |
| Gene Card | SCIMP |
| Uniprot ID | Q6UWF3 |
| Pfam | PF15050 |
| In ASD | no |
| Allosteric Prediction | no (-1.302059468) |
| Ortholog in Animals | Alpaca_ SCIMP ( ortholog_one2one ) Dog_ SCIMP ( ortholog_one2one ) GuineaPig_ SCIMP ( ortholog_one2one ) Macaque_ SCIMP ( ortholog_one2one ) Mouse_ Scimp ( ortholog_one2one ) Pig_ SCIMP ( ortholog_one2one ) Rat_ Scimp ( ortholog_one2one ) Rabbit_ SCIMP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BCL2L11, MEI1 |
| Tissue | lymph.node, spleen, adipose.tissue, lung |
| Tissue Specificity | Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level) (PubMed:21930792). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells (PubMed:21930792). Faintly expressed in the majority of nonimmune system tissues (PubMed:21930792). {ECO:0000269|PubMed:21930792}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21930792}; Lipid-anchor {ECO:0000269|PubMed:21930792}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q3UU41}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q3UU41}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q3UU41}. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs) (PubMed:21930792). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T-cells (PubMed:21930792). Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod (PubMed:21930792). Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:21930792). Localizes to phagosomes in dendritic cells after exposure to particulate beta-glucan (By similarity). {ECO:0000250|UniProtKB:Q3UU41, ECO:0000269|PubMed:21930792}. |
| Mouse PG classification | NA |
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