| Gene Information | |
|---|---|
| Gene Name | PI4KA |
| Organism | Homo sapiens (Human) |
| Gene Length | 2102 |
| Protein Names | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000241973 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P42356 |
| Gene Card | PI4KA |
| Uniprot ID | P42356 |
| Pfam | PF00454; PF00613; PF19274 |
| In ASD | no |
| Allosteric Prediction | no (-0.240500716) |
| Ortholog in Animals | Alpaca_ PI4KA ( ortholog_one2one ) Dog_ PI4KA ( ortholog_one2one ) GuineaPig_ PI4KA ( ortholog_one2one ) Macaque_ PI4KA ( ortholog_one2one ) Mouse_ Pi4ka ( ortholog_one2one ) Pig_ PI4KA ( ortholog_one2one ) Rat_ Pi4ka ( ortholog_one2one ) Rabbit_ PI4KA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PIK3CG, PIK3CB, PIK3C2B, PIK3C2A, PI4KB, PIK3CA, PIK3C2G, PIK3C3, PIK3CD |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:7961848}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6BQ1 (EM 3.60A ) |
| DBSNP | rs759091754 rs17819211 rs1298440445 rs1490645147 rs1351749039 rs144363917 rs776650691 rs888913273 rs142690596 rs2539908 rs747119727 rs773127016 rs770450191 rs1601301648 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. Cell membrane {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. Note=Localization to the plasma membrane is mediated by the PI4K complex and association with EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2) (PubMed:23229899). Localization to the plasma membrane is regulated by TMEM150A (PubMed:25608530). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25608530}. |
| Mouse PG classification | NA |
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