| Gene Information | |
|---|---|
| Gene Name | CCKBR |
| Organism | Homo sapiens (Human) |
| Gene Length | 447 |
| Protein Names | Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) |
| Target Name | gastrin/cholecystokinin type b receptor |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000110148 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P32239 |
| Gene Card | CCKBR |
| Uniprot ID | P32239 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.011223544) |
| Ortholog in Animals | Dog_ CCKBR ( ortholog_one2one ) GuineaPig_ CCKBR ( ortholog_one2one ) Macaque_ CCKBR ( ortholog_one2one ) Mouse_ Cckbr ( ortholog_one2one ) Rat_ Cckbr ( ortholog_one2one ) Rabbit_ CCKBR ( ortholog_one2one ) |
| Ohnologs | CCKAR |
| Paralogs | CCKAR, NPFFR1, HCRTR2, HCRTR1, NPFFR2, OXTR, AVPR2, AVPR1B, AVPR1A, GNRHR, GALR3, GPR22, GPR150, FFAR4, GALR1, QRFPR |
| Tissue | brain, pancreas, stomach, cerebellum, cerebral.cortex |
| Tissue Specificity | Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. {ECO:0000269|PubMed:10913157, ECO:0000269|PubMed:12429993, ECO:0000269|PubMed:7848914, ECO:0000269|PubMed:7887934, ECO:0000269|PubMed:8185170, ECO:0000269|PubMed:8349705}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1L4T (NMR - ) 7F8V (EM 3.30A ) 7F8W (EM 3.10A ) 7XOW (EM 3.10A ) 7XOX (EM 3.10A ) |
| DBSNP | rs1805000 rs35816985 rs1805002 rs1805004 rs1805001 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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