| Gene Information | |
|---|---|
| Gene Name | MC2R |
| Organism | Homo sapiens (Human) |
| Gene Length | 297 |
| Protein Names | Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) |
| Target Name | adrenocorticotropic hormone receptor |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000185231 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q01718 |
| Gene Card | MC2R |
| Uniprot ID | Q01718 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.726913758) |
| Ortholog in Animals | Alpaca_ MC2R ( ortholog_one2one ) Dog_ MC2R ( ortholog_one2one ) GuineaPig_ MC2R ( ortholog_one2one ) Mouse_ Mc2r ( ortholog_one2one ) Pig_ MC2R ( ortholog_one2one ) Rat_ Mc2r ( ortholog_one2one ) Rabbit_ MC2R ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | S1PR1, S1PR5, S1PR2, S1PR3, S1PR4, LPAR1, LPAR2, LPAR3, GPR3, GPR119, GPR6, GPR12, CNR1, CNR2, MC5R, MC3R, MC4R, MC1R |
| Tissue | adrenal.gland |
| Tissue Specificity | Melanocytes and corticoadrenal tissue. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);0.200000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs28926178 rs104894658 rs768093045 rs104894661 rs104894656 rs104894657 rs1208417750 rs104894660 rs758709668 rs104894662 rs28940892 rs28926182 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | HPG |
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