| Gene Information | |
|---|---|
| Gene Name | MICB |
| Organism | Homo sapiens (Human) |
| Gene Length | 383 |
| Protein Names | MHC class I polypeptide-related sequence B (MIC-B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000204516 ) 3 ( ENSG00000206449 ) 3 ( ENSG00000224378 ) 3 ( ENSG00000227772 ) 3 ( ENSG00000231179 ) 3 ( ENSG00000231372 ) 3 ( ENSG00000234218 ) 3 ( ENSG00000238289 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q29980 |
| Gene Card | MICB |
| Uniprot ID | Q29980 |
| Pfam | PF07654; PF00129 |
| In ASD | no |
| Allosteric Prediction | no (-1.038170994) |
| Ortholog in Animals | Mouse_ Mill1 ( ortholog_many2many ) Mouse_ Mill2 ( ortholog_many2many ) Rat_ Mill1 ( ortholog_many2many ) Rat_ Micb ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | HLA-B, HLA-E, HLA-A, HLA-F, HLA-G, HLA-C, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, MICA, AZGP1, HFE, MR1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue. {ECO:0000269|PubMed:10359807, ECO:0000269|PubMed:12569559, ECO:0000269|PubMed:17565371}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JE6 (X-ray 2.50A ) 2WY3 (X-ray 1.80A ) |
| DBSNP | rs45578846 rs45583740 rs3131639 rs1065075 rs45486091 rs45502297 rs3134900 rs1051788 rs1051788 rs41293883 rs45624537 rs45587032 rs41273040 rs45470602 rs1065076 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q29983}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29983}. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q29983, ECO:0000269|PubMed:12782710}. |
| Mouse PG classification | NA |
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