| Gene Information | |
|---|---|
| Gene Name | RHOV |
| Organism | Homo sapiens (Human) |
| Gene Length | 236 |
| Protein Names | Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000104140 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q96L33 |
| Gene Card | RHOV |
| Uniprot ID | Q96L33 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-1.000133699) |
| Ortholog in Animals | Alpaca_ RHOV ( ortholog_one2one ) Dog_ RHOV ( ortholog_one2one ) GuineaPig_ RHOV ( ortholog_one2one ) Macaque_ RHOV ( ortholog_one2one ) Mouse_ Rhov ( ortholog_one2one ) Pig_ RHOV ( ortholog_one2one ) Rat_ Rhov ( ortholog_one2one ) Rabbit_ RHOV ( ortholog_one2one ) |
| Ohnologs | RHOU |
| Paralogs | RND1, CDC42, RHOT1, RHOBTB3, RHOT2, RAC1, RAC3, RHOJ, RHOA, RHOC, RHOB, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RHOU, RAC2, RHOBTB1, RHOH |
| Tissue | esophagus, skin, tonsil, tongue, zone.of.skin, esophagus.mucosa, lower.leg.skin, suprapubic.skin, vagina |
| Tissue Specificity | Highly expressed in pancreas, placenta, and fetal brain. {ECO:0000269|PubMed:11956592}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z1Y0}. Endosome membrane {ECO:0000250|UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z1Y0}. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250|UniProtKB:Q9Z1Y0}. |
| Mouse PG classification | NA |
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