| Gene Information | |
|---|---|
| Gene Name | CCDC21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 762 |
| Protein Names | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q6P2H3 |
| Gene Card | CEP85 |
| Uniprot ID | Q6P2H3 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5OI7 (X-ray 1.67A ) 5OID (X-ray 4.60A ) |
| DBSNP | rs35831900 rs3795686 rs7550997 rs36013141 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:26220856}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:26220856}. Nucleus, nucleolus {ECO:0000269|PubMed:21399614}. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles (PubMed:21399614). Associated with the pericentriolar material. Localizes to centrosomes at a low level in G1 phase and a slightly increased level in S phase, with gradually elevated levels during G2 phase. The levels at centrosomes further increase at G2/M, reaching a peak at spindle poles at early mitotic stages and remain high until the end of anaphase (PubMed:26220856). {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:26220856}. |
| Mouse PG classification | NA |
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