| Gene Information | |
|---|---|
| Gene Name | CPLX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 134 |
| Protein Names | Complexin-1 (Complexin I) (CPX I) (Synaphin-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000168993 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14810 |
| Gene Card | CPLX1 |
| Uniprot ID | O14810 |
| Pfam | PF05835 |
| In ASD | no |
| Allosteric Prediction | no (-0.959765007) |
| Ortholog in Animals | Alpaca_ CPLX1 ( ortholog_one2one ) Dog_ CPLX1 ( ortholog_one2one ) GuineaPig_ CPLX1 ( ortholog_one2one ) Macaque_ CPLX1 ( ortholog_one2one ) Mouse_ Cplx1 ( ortholog_one2one ) Pig_ CPLX1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CPLX4, CPLX3, CPLX2 |
| Tissue | brain, cerebral.cortex, adrenal.gland |
| Tissue Specificity | Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:15526345, ECO:0000269|PubMed:9853440}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3RK3 (X-ray 3.50A ) 3RL0 (X-ray 3.80A ) |
| DBSNP | rs371709824 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P63040}. Perikaryon {ECO:0000250|UniProtKB:P63040}. Presynapse {ECO:0000250|UniProtKB:P63040}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250|UniProtKB:P63040}. |
| Mouse PG classification | NA |
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