| Gene Information | |
|---|---|
| Gene Name | PLD6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 252 |
| Protein Names | Mitochondrial cardiolipin hydrolase (EC 3.1.4.-) (Choline phosphatase 6) (Mitochondrial phospholipase) (MitoPLD) (Phosphatidylcholine-hydrolyzing phospholipase D6) (Phospholipase D6) (PLD6) (Protein zucchini homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000179598 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8N2A8 |
| Gene Card | PLD6 |
| Uniprot ID | Q8N2A8 |
| Pfam | PF13091 |
| In ASD | no |
| Allosteric Prediction | no (-1.14034226) |
| Ortholog in Animals | Alpaca_ PLD6 ( ortholog_one2one ) Dog_ PLD6 ( ortholog_one2one ) GuineaPig_ PLD6 ( ortholog_one2one ) Macaque_ PLD6 ( ortholog_one2one ) Mouse_ Pld6 ( ortholog_one2one ) Pig_ PLD6 ( ortholog_one2one ) Rat_ Pld6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in testis and ovary, but not limited to gonads (at protein level) (PubMed:17028579, PubMed:21397847). It is also found in brain, heart, pituitary gland, prostate, pancreas, thyroid, bone marrow, lung and muscle (PubMed:21397847). {ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397847}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17856924 rs11551966 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:17028579}; Single-pass membrane protein {ECO:0000269|PubMed:17028579}. Golgi apparatus {ECO:0000250|UniProtKB:Q5SWZ9}. Note=Localization in the mitochondrial outer membrane is found in different cell types where phospholipase is the predominant activity, however, in pachytene spermatocytes and spermatids of mouse testes where nuclease activity is predominant, localization is restricted to the Golgi, suggesting this enzyme is localized in different subcellular compartments depending on the role (phospholipase or nuclease) it needs to play in each cell type and developmental stage. {ECO:0000305}. |
| Mouse PG classification | NA |
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