| Gene Information | |
|---|---|
| Gene Name | KNTC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2209 |
| Protein Names | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000184445 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P50748 |
| Gene Card | KNTC1 |
| Uniprot ID | P50748 |
| Pfam | PF10493 |
| In ASD | no |
| Allosteric Prediction | no (-0.196474883) |
| Ortholog in Animals | Alpaca_ KNTC1 ( ortholog_one2one ) Dog_ KNTC1 ( ortholog_one2one ) GuineaPig_ KNTC1 ( ortholog_one2one ) Macaque_ KNTC1 ( ortholog_one2one ) Mouse_ Kntc1 ( ortholog_one2one ) Pig_ KNTC1 ( ortholog_one2one ) Rat_ Kntc1 ( ortholog_one2one ) Rabbit_ KNTC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | spleen, testis |
| Tissue Specificity | High expression in testis. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.12(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7QPG (EM 3.90A ) |
| DBSNP | rs7968222 rs17883249 rs35315099 rs7310898 rs11837038 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles. |
| Mouse PG classification | NA |
| click here to return to the previous page | |