| Gene Information | |
|---|---|
| Gene Name | RHOU |
| Organism | Homo sapiens (Human) |
| Gene Length | 258 |
| Protein Names | Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000116574 ) 3 ( ENSG00000284984 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7L0Q8 |
| Gene Card | RHOU |
| Uniprot ID | Q7L0Q8 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.565660773) |
| Ortholog in Animals | Alpaca_ RHOU ( ortholog_one2one ) Dog_ RHOU ( ortholog_one2one ) GuineaPig_ RHOU ( ortholog_one2one ) Macaque_ RHOU ( ortholog_one2one ) Mouse_ Rhou ( ortholog_one2one ) Pig_ RHOU ( ortholog_one2one ) Rat_ Rhou ( ortholog_one2one ) Rabbit_ RHOU ( ortholog_one2one ) |
| Ohnologs | RHOV |
| Paralogs | RND1, CDC42, RHOT1, RHOBTB3, RHOT2, RAC1, RAC3, RHOJ, RHOA, RHOC, RHOB, RHOV, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RAC2, RHOBTB1, RHOH |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. {ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:14731133}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2Q3H (X-ray 1.73A ) |
| DBSNP | rs3820264 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Lipid-anchor {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Cytoplasmic side {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Golgi apparatus membrane {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Lipid-anchor {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Cell junction, focal adhesion {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Cell projection, podosome {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Note=Localizes to podosomes in SRC-transformed cells. {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. |
| Mouse PG classification | NA |
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