| Gene Information | |
|---|---|
| Gene Name | UCP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 312 |
| Protein Names | Mitochondrial uncoupling protein 3 (UCP 3) (Solute carrier family 25 member 9) |
| Target Name | mitochondrial uncoupling protein 3 |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000175564 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P55916 |
| Gene Card | UCP3 |
| Uniprot ID | P55916 |
| Pfam | PF00153 |
| In ASD | no |
| Allosteric Prediction | yes (0.373493864) |
| Ortholog in Animals | Alpaca_ UCP3 ( ortholog_one2one ) Dog_ UCP3 ( ortholog_one2one ) GuineaPig_ UCP3 ( ortholog_one2one ) Macaque_ UCP3 ( ortholog_one2one ) Mouse_ Ucp3 ( ortholog_one2one ) Pig_ UCP3 ( ortholog_one2one ) Rat_ Ucp3 ( ortholog_one2one ) Rabbit_ UCP3 ( ortholog_one2one ) |
| Ohnologs | UCP1 |
| Paralogs | SLC25A23, SLC25A35, SLC25A38, SLC25A12, SLC25A11, SLC25A22, SLC25A29, SLC25A21, SLC25A48, SLC25A42, SLC25A3, SLC25A28, UCP2, UCP1, SLC25A34, SLC25A15, SLC25A32, SLC25A53, SLC25A4, SLC25A40, SLC25A10, SLC25A18, SLC25A24, SLC25A44, SLC25A31, SLC25A5, SLC25A39, SLC25A36, SLC25A14, SLC25A27, SLC25A1, SLC25A41, SLC25A43, SLC25A47, SLC25A20, SLC25A37, SLC25A13, SLC25A33, SLC25A25, SLC25A26, SLC25A6, SLC25A45, SLC25A2, SLC25A51, SLC25A52, SLC25A30, SLC25A19, SLC25A16, SLC25A17 |
| Tissue | skeletal.muscle, artery, penis |
| Tissue Specificity | Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles. {ECO:0000269|PubMed:9196039}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs8179180 rs17848368 rs2229707 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | LPG |
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