| Gene Information | |
|---|---|
| Gene Name | CCAR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 923 |
| Protein Names | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000158941 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8N163 |
| Gene Card | CCAR2 |
| Uniprot ID | Q8N163 |
| Pfam | PF19257; PF14443; PF19256; PF14444 |
| In ASD | no |
| Allosteric Prediction | no (-0.273528334) |
| Ortholog in Animals | Alpaca_ CCAR2 ( ortholog_one2one ) Dog_ CCAR2 ( ortholog_one2one ) GuineaPig_ CCAR2 ( ortholog_one2one ) Macaque_ CCAR2 ( ortholog_one2one ) Mouse_ Ccar2 ( ortholog_one2one ) Pig_ CCAR2 ( ortholog_one2one ) Rat_ Ccar2 ( ortholog_one2one ) Rabbit_ CCAR2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCAR1 |
| Tissue | NA |
| Tissue Specificity | Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level). Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. {ECO:0000269|PubMed:12370419, ECO:0000269|PubMed:24962073}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:25661920}. Cytoplasm {ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:24824780}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Note=Recruited to chromatin, post-UV irradiation. Sequestered to the cytoplasm in the presence of MCC. Translocated to the cytoplasm during UV-induced apoptosis. {ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:24824780}. |
| Mouse PG classification | NA |
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