| Gene Information | |
|---|---|
| Gene Name | CBX5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 191 |
| Protein Names | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) |
| Target Name | chromobox protein homolog 5 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000094916 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P45973 |
| Gene Card | CBX5 |
| Uniprot ID | P45973 |
| Pfam | PF00385; PF01393 |
| In ASD | no |
| Allosteric Prediction | no (-0.513591513) |
| Ortholog in Animals | Alpaca_ CBX5 ( ortholog_one2one ) Dog_ CBX5 ( ortholog_one2one ) GuineaPig_ CBX5 ( ortholog_one2one ) Macaque_ CBX5 ( ortholog_one2one ) Mouse_ Cbx5 ( ortholog_one2one ) Pig_ CBX5 ( ortholog_one2one ) Rat_ Cbx5 ( ortholog_one2one ) Rabbit_ CBX5 ( ortholog_one2one ) |
| Ohnologs | CBX1, CBX3 |
| Paralogs | CBX6, NPTXR, CBX1, CBX3, CBX4, CBX7, CBX2, CBX8 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.029403(Rat);0.038220(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FDT (X-ray 2.00A ) 3I3C (X-ray 2.48A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:19617346}. Chromosome {ECO:0000269|PubMed:10460410}. Chromosome, centromere {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:21346195}. Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. {ECO:0000269|PubMed:19617346}. |
| Mouse PG classification | NA |
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